diff --git a/biology/py-resdk/Makefile b/biology/py-resdk/Makefile
index f04db08f522d..8e59235bc051 100644
--- a/biology/py-resdk/Makefile
+++ b/biology/py-resdk/Makefile
@@ -1,5 +1,5 @@
 PORTNAME=	resdk
-DISTVERSION=	20.0.0
+DISTVERSION=	21.1.0
 CATEGORIES=	biology python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
diff --git a/biology/py-resdk/distinfo b/biology/py-resdk/distinfo
index 7e37d337db99..d5b29d97a088 100644
--- a/biology/py-resdk/distinfo
+++ b/biology/py-resdk/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1698476837
-SHA256 (resdk-20.0.0.tar.gz) = 56728eac8971c7f4c7eca2573a4783bb75373a083b2c1e0a8066e5267a7328df
-SIZE (resdk-20.0.0.tar.gz) = 256197
+TIMESTAMP = 1712349634
+SHA256 (resdk-21.1.0.tar.gz) = 96d5bf0721eee006360f0b1116310a509028160aded47a82e1ac1992f5fe6105
+SIZE (resdk-21.1.0.tar.gz) = 258889