diff --git a/science/py-py3Dmol/Makefile b/science/py-py3Dmol/Makefile
index 870b589e361c..58c39e74e616 100644
--- a/science/py-py3Dmol/Makefile
+++ b/science/py-py3Dmol/Makefile
@@ -1,5 +1,5 @@
 PORTNAME=	py3Dmol
-DISTVERSION=	1.8.1
+DISTVERSION=	2.0.3
 CATEGORIES=	science python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
@@ -12,6 +12,7 @@ LICENSE=	WTFPL
 LICENSE_FILE=	${WRKSRC}/LICENSE.txt
 
 BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}ipython>0:devel/ipython@${PY_FLAVOR}
+RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}ipython>0:devel/ipython@${PY_FLAVOR}
 
 USES=		python
 USE_PYTHON=	distutils autoplist
diff --git a/science/py-py3Dmol/distinfo b/science/py-py3Dmol/distinfo
index eebdc6c38f5e..80b36b3d53bb 100644
--- a/science/py-py3Dmol/distinfo
+++ b/science/py-py3Dmol/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1660247804
-SHA256 (py3Dmol-1.8.1.tar.gz) = 10bb3022c5db3e5e6d66f51d7d4118afaf939726d655f08761709ddf032cb31d
-SIZE (py3Dmol-1.8.1.tar.gz) = 7125
+TIMESTAMP = 1690940097
+SHA256 (py3Dmol-2.0.3.tar.gz) = b2725e3a64a838c21342e5e4b56c343b41d90cf18fb61f7cc6a1130a1705e443
+SIZE (py3Dmol-2.0.3.tar.gz) = 7712