diff --git a/science/afni/Makefile b/science/afni/Makefile
index 14e5cf84709b..3e77c9f4f621 100644
--- a/science/afni/Makefile
+++ b/science/afni/Makefile
@@ -2,7 +2,7 @@
 
 PORTNAME=		afni
 DISTVERSIONPREFIX=	AFNI_
-DISTVERSION=		20.2.19
+DISTVERSION=		20.3.00
 CATEGORIES=		science biology graphics perl5 python
 
 MAINTAINER=	ports@FreeBSD.org
diff --git a/science/afni/distinfo b/science/afni/distinfo
index 8b20dae74775..06fb930f5247 100644
--- a/science/afni/distinfo
+++ b/science/afni/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1601317267
-SHA256 (afni-afni-AFNI_20.2.19_GH0.tar.gz) = f8e85ab6fd4d0a5436717e96c8749990d91e83c696f5538f780f662c00430bff
-SIZE (afni-afni-AFNI_20.2.19_GH0.tar.gz) = 42704724
+TIMESTAMP = 1601731382
+SHA256 (afni-afni-AFNI_20.3.00_GH0.tar.gz) = 5a3178d9277c84ee8701e63fdc6369405a3110aafd13b4d0057bfda76a19bca1
+SIZE (afni-afni-AFNI_20.3.00_GH0.tar.gz) = 42703999