diff --git a/math/py-rpy2/Makefile b/math/py-rpy2/Makefile
index ca7625f9c932..d8ca7a9e3f0c 100644
--- a/math/py-rpy2/Makefile
+++ b/math/py-rpy2/Makefile
@@ -2,8 +2,7 @@
 # $FreeBSD$
 
 PORTNAME=	rpy2
-DISTVERSION=	3.2.0
-PORTREVISION=	1
+DISTVERSION=	3.2.1
 CATEGORIES=	math
 MASTER_SITES=	CHEESESHOP
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
@@ -14,12 +13,12 @@ COMMENT=	Python interface to the R Programming Language
 LICENSE=	GPLv2+
 LICENSE_FILE=	${WRKSRC}/gpl-2.0.txt
 
-BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}cffi>=1.10.0:devel/py-cffi@${PY_FLAVOR}
+BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}cffi>=1.13.1:devel/py-cffi@${PY_FLAVOR}
 LIB_DEPENDS=	libR.so:math/R \
 		libicui18n.so:devel/icu \
 		libomp.so:devel/openmp \
 		libpcre.so:devel/pcre
-RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}cffi>=1.10.0:devel/py-cffi@${PY_FLAVOR} \
+RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}cffi>=1.13.1:devel/py-cffi@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}Jinja2>0:devel/py-Jinja2@${PY_FLAVOR} \
 		${PYNUMPY} \
 		${PYTHON_PKGNAMEPREFIX}pytz>=0:devel/py-pytz@${PY_FLAVOR} \
diff --git a/math/py-rpy2/distinfo b/math/py-rpy2/distinfo
index af6129126557..a79cc555629d 100644
--- a/math/py-rpy2/distinfo
+++ b/math/py-rpy2/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1569809145
-SHA256 (rpy2-3.2.0.tar.gz) = 18025f53c1a32b7b38ed319c81f8445b9a8809e0ecba210634b67764d68da978
-SIZE (rpy2-3.2.0.tar.gz) = 161566
+TIMESTAMP = 1571759817
+SHA256 (rpy2-3.2.1.tar.gz) = cfba1b5d5ad56f9f52a0df4df8015a342043f113576003967fd760e063023ca6
+SIZE (rpy2-3.2.1.tar.gz) = 161983