diff --git a/math/py-rpy2/Makefile b/math/py-rpy2/Makefile
index fd62a797b371..25e36b2728f5 100644
--- a/math/py-rpy2/Makefile
+++ b/math/py-rpy2/Makefile
@@ -2,8 +2,7 @@
 # $FreeBSD$
 
 PORTNAME=	rpy2
-DISTVERSION=	2.9.5
-PORTREVISION=	1
+DISTVERSION=	3.0.1
 CATEGORIES=	math
 MASTER_SITES=	CHEESESHOP
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
@@ -14,19 +13,22 @@ COMMENT=	Python interface to the R Programming Language
 LICENSE=	GPLv2+
 LICENSE_FILE=	${WRKSRC}/gpl-2.0.txt
 
-BUILD_DEPENDS=	${PYNUMPY}
+BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}cffi>=1.0.0:devel/py-cffi@${PY_FLAVOR}
 LIB_DEPENDS=	libR.so:math/R \
 		libicui18n.so:devel/icu \
 		libomp.so:devel/openmp \
 		libpcre.so:devel/pcre
-RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}Jinja2>0:devel/py-Jinja2@${PY_FLAVOR} \
+RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}cffi>=1.0.0:devel/py-cffi@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}Jinja2>0:devel/py-Jinja2@${PY_FLAVOR} \
 		${PYNUMPY} \
-		${PYTHON_PKGNAMEPREFIX}six>0:devel/py-six@${PY_FLAVOR}
+		${PYTHON_PKGNAMEPREFIX}simplegeneric>=0:devel/py-simplegeneric@${PY_FLAVOR}
 
 USES=		fortran python:3.5+ readline
 USE_PYTHON=	autoplist distutils
 
-post-install:
-	@${STRIP_CMD} ${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}/rpy2/rinterface/*.so
+NO_ARCH=	yes
+
+pre-build:
+	cd ${WRKSRC}/ && ${PYTHON_CMD} rpy/_rinterface_cffi_build.py
 
 .include <bsd.port.mk>
diff --git a/math/py-rpy2/distinfo b/math/py-rpy2/distinfo
index d27a5f61332b..a103d89621cc 100644
--- a/math/py-rpy2/distinfo
+++ b/math/py-rpy2/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1543763107
-SHA256 (rpy2-2.9.5.tar.gz) = b91f8efca7d0929f2b2b3634946be892cba6c21f92acdf737399e7eedf4532db
-SIZE (rpy2-2.9.5.tar.gz) = 194145
+TIMESTAMP = 1551634105
+SHA256 (rpy2-3.0.1.tar.gz) = eb288092d139d36cf1e87e5fbcb6c651c24c186f44c41fc8773578ab2543abcf
+SIZE (rpy2-3.0.1.tar.gz) = 117128