diff --git a/science/rdkit/Makefile b/science/rdkit/Makefile
index 60a67c52b210..5955a1aa4706 100644
--- a/science/rdkit/Makefile
+++ b/science/rdkit/Makefile
@@ -1,6 +1,6 @@
 PORTNAME=	rdkit
 DISTVERSIONPREFIX=	Release_
-DISTVERSION=	2021_09_5
+DISTVERSION=	2022_03_1
 CATEGORIES=	science
 MASTER_SITES=	https://fonts.google.com/download?family=Comic%20Neue&dummy=/:font
 DISTFILES=	Comic_Neue.zip:font
diff --git a/science/rdkit/distinfo b/science/rdkit/distinfo
index 68ede7312213..2206e854b4a0 100644
--- a/science/rdkit/distinfo
+++ b/science/rdkit/distinfo
@@ -1,7 +1,7 @@
-TIMESTAMP = 1646530099
-SHA256 (rdkit-2021.09.5/Comic_Neue.zip) = b90d32da89882e5eea971682a83efa0feac9e5d9db1e43070c9eea7a87f96ff5
-SIZE (rdkit-2021.09.5/Comic_Neue.zip) = 180686
-SHA256 (rdkit-2021.09.5/rdkit-rdkit-Release_2021_09_5_GH0.tar.gz) = f720b3f6292c4cd0a412a073d848ffac01a43960082e33ee54b68798de0cbfa1
-SIZE (rdkit-2021.09.5/rdkit-rdkit-Release_2021_09_5_GH0.tar.gz) = 78481014
-SHA256 (rdkit-2021.09.5/rareylab-RingDecomposerLib-v1.1.3_rdkit_GH0.tar.gz) = 944b5816712a48bbf88aa25d4300ce11871ddf6e971218eac08f90ed2192f715
-SIZE (rdkit-2021.09.5/rareylab-RingDecomposerLib-v1.1.3_rdkit_GH0.tar.gz) = 137931
+TIMESTAMP = 1648501898
+SHA256 (rdkit-2022.03.1/Comic_Neue.zip) = b90d32da89882e5eea971682a83efa0feac9e5d9db1e43070c9eea7a87f96ff5
+SIZE (rdkit-2022.03.1/Comic_Neue.zip) = 180686
+SHA256 (rdkit-2022.03.1/rdkit-rdkit-Release_2022_03_1_GH0.tar.gz) = 9ded69eeb38a91bd09cd5d5dc69e7f1f87e1412ab8beef29207988fb81dfd5f5
+SIZE (rdkit-2022.03.1/rdkit-rdkit-Release_2022_03_1_GH0.tar.gz) = 78560198
+SHA256 (rdkit-2022.03.1/rareylab-RingDecomposerLib-v1.1.3_rdkit_GH0.tar.gz) = 944b5816712a48bbf88aa25d4300ce11871ddf6e971218eac08f90ed2192f715
+SIZE (rdkit-2022.03.1/rareylab-RingDecomposerLib-v1.1.3_rdkit_GH0.tar.gz) = 137931
diff --git a/science/rdkit/pkg-plist b/science/rdkit/pkg-plist
index 59fdb2622d46..9f3b100ad4c4 100644
--- a/science/rdkit/pkg-plist
+++ b/science/rdkit/pkg-plist
@@ -163,6 +163,7 @@ include/rdkit/GraphMol/FragCatalog/FragCatParams.h
 include/rdkit/GraphMol/FragCatalog/FragCatalogEntry.h
 include/rdkit/GraphMol/FragCatalog/FragCatalogUtils.h
 include/rdkit/GraphMol/FragCatalog/FragFPGenerator.h
+include/rdkit/GraphMol/GenericGroups/GenericGroups.h
 include/rdkit/GraphMol/GraphMol.h
 include/rdkit/GraphMol/MMPA/MMPA.h
 include/rdkit/GraphMol/MolAlign/AlignMolecules.h
@@ -175,13 +176,8 @@ include/rdkit/GraphMol/MolChemicalFeatures/FeatureParser.h
 include/rdkit/GraphMol/MolChemicalFeatures/MolChemicalFeature.h
 include/rdkit/GraphMol/MolChemicalFeatures/MolChemicalFeatureDef.h
 include/rdkit/GraphMol/MolChemicalFeatures/MolChemicalFeatureFactory.h
-include/rdkit/GraphMol/MolDraw2D/DrawText.h
-include/rdkit/GraphMol/MolDraw2D/DrawTextFT.h
-include/rdkit/GraphMol/MolDraw2D/DrawTextFTJS.h
-include/rdkit/GraphMol/MolDraw2D/DrawTextFTSVG.h
-include/rdkit/GraphMol/MolDraw2D/DrawTextJS.h
-include/rdkit/GraphMol/MolDraw2D/DrawTextSVG.h
 include/rdkit/GraphMol/MolDraw2D/MolDraw2D.h
+include/rdkit/GraphMol/MolDraw2D/MolDraw2DHelpers.h
 include/rdkit/GraphMol/MolDraw2D/MolDraw2DJS.h
 include/rdkit/GraphMol/MolDraw2D/MolDraw2DSVG.h
 include/rdkit/GraphMol/MolDraw2D/MolDraw2DUtils.h
@@ -388,6 +384,9 @@ lib/libRDKitForceFieldHelpers.so.1.%%SHLIB_VER%%
 lib/libRDKitFragCatalog.so
 lib/libRDKitFragCatalog.so.1
 lib/libRDKitFragCatalog.so.1.%%SHLIB_VER%%
+lib/libRDKitGenericGroups.so
+lib/libRDKitGenericGroups.so.1
+lib/libRDKitGenericGroups.so.1.%%SHLIB_VER%%
 lib/libRDKitGraphMol.so
 lib/libRDKitGraphMol.so.1
 lib/libRDKitGraphMol.so.1.%%SHLIB_VER%%
@@ -513,6 +512,7 @@ lib/libRDKitga.so.1.%%SHLIB_VER%%
 %%PYTHON%%%%PYTHON_SITELIBDIR%%/rdkit/Chem/Descriptors3D.py
 %%PYTHON%%%%PYTHON_SITELIBDIR%%/rdkit/Chem/Draw/FreeSans.ttf
 %%PYTHON%%%%PYTHON_SITELIBDIR%%/rdkit/Chem/Draw/IPythonConsole.py
+%%PYTHON%%%%PYTHON_SITELIBDIR%%/rdkit/Chem/Draw/InteractiveRenderer.py
 %%PYTHON%%%%PYTHON_SITELIBDIR%%/rdkit/Chem/Draw/MolDrawing.py
 %%PYTHON%%%%PYTHON_SITELIBDIR%%/rdkit/Chem/Draw/SimilarityMaps.py
 %%PYTHON%%%%PYTHON_SITELIBDIR%%/rdkit/Chem/Draw/__init__.py
@@ -625,7 +625,9 @@ lib/libRDKitga.so.1.%%SHLIB_VER%%
 %%PYTHON%%%%PYTHON_SITELIBDIR%%/rdkit/Chem/fmcs/fmcs
 %%PYTHON%%%%PYTHON_SITELIBDIR%%/rdkit/Chem/fmcs/fmcs.py
 %%PYTHON%%%%PYTHON_SITELIBDIR%%/rdkit/Chem/inchi.py
+%%PYTHON%%%%PYTHON%%%%PYTHON_SITELIBDIR%%/rdkit/Chem/nbtests/ChEMBL_quinolones.tsv
 %%PYTHON%%%%PYTHON_SITELIBDIR%%/rdkit/Chem/nbtests/github4823.ipynb
+%%PYTHON%%%%PYTHON_SITELIBDIR%%/rdkit/Chem/nbtests/rdkit-structure-renderer.ipynb
 %%PYTHON%%%%PYTHON_SITELIBDIR%%/rdkit/Chem/rdAbbreviations.so
 %%PYTHON%%%%PYTHON_SITELIBDIR%%/rdkit/Chem/rdCIPLabeler.so
 %%PYTHON%%%%PYTHON_SITELIBDIR%%/rdkit/Chem/rdChemReactions.so