diff --git a/pkgs/development/python-modules/sqlite-vec/default.nix b/pkgs/development/python-modules/sqlite-vec/default.nix
new file mode 100644
index 000000000000..09fcf06304af
--- /dev/null
+++ b/pkgs/development/python-modules/sqlite-vec/default.nix
@@ -0,0 +1,85 @@
+{
+  lib,
+  buildPythonPackage,
+  fetchpatch,
+
+  # build-system
+  setuptools,
+  setuptools-scm,
+
+  # dependencies
+  sqlite-vec-c, # alias for pkgs.sqlite-vec
+
+  # optional dependencies
+  numpy,
+
+  # check inputs
+  openai,
+  pytestCheckHook,
+}:
+
+buildPythonPackage rec {
+  inherit (sqlite-vec-c) pname version src;
+  pyproject = true;
+
+  # The actual source root is bindings/python but the patches
+  # apply to the bindings directory.
+  # This is a known issue, see https://discourse.nixos.org/t/how-to-apply-patches-with-sourceroot/59727
+  sourceRoot = "${src.name}/bindings";
+
+  patches = [
+    (fetchpatch {
+      # https://github.com/asg017/sqlite-vec/pull/233
+      name = "add-python-build-files.patch";
+      url = "https://github.com/asg017/sqlite-vec/commit/c1917deb11aa79dcac32440679345b93e13b1b86.patch";
+      hash = "sha256-4/9QLKuM/1AbD8AQHwJ14rhWVYVc+MILvK6+tWwWQlw=";
+      stripLen = 1;
+    })
+    (fetchpatch {
+      # https://github.com/asg017/sqlite-vec/pull/233
+      name = "add-python-test.patch";
+      url = "https://github.com/asg017/sqlite-vec/commit/608972c9dcbfc7f4583e99fd8de6e5e16da11081.patch";
+      hash = "sha256-8dfw7zs7z2FYh8DoAxurMYCDMOheg8Zl1XGcPw1A1BM=";
+      stripLen = 1;
+    })
+  ];
+
+  # Change into the proper directory for building, move `extra_init.py` into its proper location,
+  # and supply the path to the library.
+  postPatch = ''
+    cd python
+    mv extra_init.py sqlite_vec/
+    substituteInPlace sqlite_vec/__init__.py \
+      --replace-fail "@libpath@" "${lib.getLib sqlite-vec-c}/lib/"
+  '';
+
+  build-system = [
+    setuptools
+    setuptools-scm
+  ];
+
+  dependencies = [
+    sqlite-vec-c
+  ];
+
+  optional-dependencies = {
+    numpy = [
+      numpy
+    ];
+  };
+
+  nativeCheckInputs = [
+    numpy
+    openai
+    pytestCheckHook
+    sqlite-vec-c
+  ];
+
+  pythonImportsCheck = [ "sqlite_vec" ];
+
+  meta = sqlite-vec-c.meta // {
+    description = "Python bindings for sqlite-vec";
+    maintainers = [ lib.maintainers.sarahec ];
+    badPlatforms = [ "x86_64-darwin" ];
+  };
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 263a5fcd1ab3..c3b0a3daf68e 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -17009,6 +17009,10 @@ self: super: with self; {
 
   sqlite-utils = callPackage ../development/python-modules/sqlite-utils { };
 
+  sqlite-vec = callPackage ../development/python-modules/sqlite-vec {
+    sqlite-vec-c = pkgs.sqlite-vec;
+  };
+
   sqlitedict = callPackage ../development/python-modules/sqlitedict { };
 
   sqliteschema = callPackage ../development/python-modules/sqliteschema { };