diff --git a/pkgs/by-name/ac/accelergy/package.nix b/pkgs/by-name/ac/accelergy/package.nix
index 40948cab7158..ccd8dfadb186 100644
--- a/pkgs/by-name/ac/accelergy/package.nix
+++ b/pkgs/by-name/ac/accelergy/package.nix
@@ -7,7 +7,7 @@
 python3Packages.buildPythonApplication {
   pname = "accelergy";
   version = "unstable-2022-05-03";
-  format = "setuptools";
+  format = "pyproject";
 
   src = fetchFromGitHub {
     owner = "Accelergy-Project";
@@ -16,11 +16,14 @@ python3Packages.buildPythonApplication {
     hash = "sha256-SRtt1EocHy5fKszpoumC+mOK/qhreoA2/Ff1wcu5WKo=";
   };
 
-  propagatedBuildInputs = with python3Packages; [
+  build-system = with python3Packages; [
+    setuptools
+  ];
+
+  dependencies = with python3Packages; [
     pyyaml
     yamlordereddictloader
     pyfiglet
-    setuptools
   ];
 
   meta = {
diff --git a/pkgs/by-name/ad/adafruit-ampy/package.nix b/pkgs/by-name/ad/adafruit-ampy/package.nix
index 7c8ada704bc6..74e7d8239d18 100644
--- a/pkgs/by-name/ad/adafruit-ampy/package.nix
+++ b/pkgs/by-name/ad/adafruit-ampy/package.nix
@@ -4,20 +4,21 @@
   fetchPypi,
 }:
 
-with python3.pkgs;
-
-buildPythonApplication rec {
+python3.pkgs.buildPythonApplication rec {
   pname = "adafruit-ampy";
   version = "1.1.0";
-  format = "setuptools";
+  format = "pyproject";
 
   src = fetchPypi {
     inherit pname version;
     sha256 = "f4cba36f564096f2aafd173f7fbabb845365cc3bb3f41c37541edf98b58d3976";
   };
 
-  nativeBuildInputs = [ setuptools-scm ];
-  propagatedBuildInputs = [
+  build-system = with python3.pkgs; [
+    setuptools
+  ];
+
+  dependencies = with python3.pkgs; [
     click
     python-dotenv
     pyserial
diff --git a/pkgs/by-name/ad/addic7ed-cli/package.nix b/pkgs/by-name/ad/addic7ed-cli/package.nix
index 8ef9ab342c82..01fadf492138 100644
--- a/pkgs/by-name/ad/addic7ed-cli/package.nix
+++ b/pkgs/by-name/ad/addic7ed-cli/package.nix
@@ -7,14 +7,18 @@
 python3Packages.buildPythonApplication rec {
   pname = "addic7ed-cli";
   version = "1.4.6";
-  format = "setuptools";
+  format = "pyproject";
 
   src = fetchPypi {
     inherit pname version;
     sha256 = "182cpwxpdybsgl1nps850ysvvjbqlnx149kri4hxhgm58nqq0qf5";
   };
 
-  propagatedBuildInputs = with python3Packages; [
+  build-system = with python3Packages; [
+    setuptools
+  ];
+
+  dependencies = with python3Packages; [
     requests
     pyquery
   ];
diff --git a/pkgs/by-name/ai/aiodnsbrute/package.nix b/pkgs/by-name/ai/aiodnsbrute/package.nix
index 12c1690b6231..b6acc1702c1a 100644
--- a/pkgs/by-name/ai/aiodnsbrute/package.nix
+++ b/pkgs/by-name/ai/aiodnsbrute/package.nix
@@ -7,7 +7,7 @@
 python3.pkgs.buildPythonApplication rec {
   pname = "aiodnsbrute";
   version = "0.3.3";
-  format = "setuptools";
+  format = "pyproject";
 
   src = fetchFromGitHub {
     owner = "blark";
@@ -16,7 +16,11 @@ python3.pkgs.buildPythonApplication rec {
     hash = "sha256-cEpk71VoQJZfKeAZummkk7yjtXKSMndgo0VleYiMlWE=";
   };
 
-  propagatedBuildInputs = with python3.pkgs; [
+  build-system = with python3.pkgs; [
+    setuptools
+  ];
+
+  dependencies = with python3.pkgs; [
     aiodns
     click
     tqdm
diff --git a/pkgs/by-name/al/almonds/package.nix b/pkgs/by-name/al/almonds/package.nix
index fbc2d42b40ee..e4e17e58d948 100644
--- a/pkgs/by-name/al/almonds/package.nix
+++ b/pkgs/by-name/al/almonds/package.nix
@@ -5,11 +5,10 @@
   ncurses,
 }:
 
-with python3.pkgs;
-buildPythonApplication rec {
+python3.pkgs.buildPythonApplication rec {
   pname = "almonds";
   version = "1.25b";
-  format = "setuptools";
+  format = "pyproject";
 
   src = fetchFromGitHub {
     owner = "Tenchi2xh";
@@ -18,11 +17,13 @@ buildPythonApplication rec {
     sha256 = "0j8d8jizivnfx8lpc4w6sbqj5hq35nfz0vdg7ld80sc5cs7jr3ws";
   };
 
-  nativeBuildInputs = [ pytest ];
-  buildInputs = [ ncurses ];
-  propagatedBuildInputs = [ pillow ];
+  build-system = with python3.pkgs; [ setuptools ];
 
-  checkPhase = "py.test";
+  dependencies = with python3.pkgs; [ pillow ];
+
+  buildInputs = [ ncurses ];
+
+  nativeCheckInputs = with python3.pkgs; [ pytestCheckHook ];
 
   meta = with lib; {
     description = "Terminal Mandelbrot fractal viewer";
diff --git a/pkgs/by-name/am/amoco/package.nix b/pkgs/by-name/am/amoco/package.nix
index 406ed970facf..e66d63630dc1 100644
--- a/pkgs/by-name/am/amoco/package.nix
+++ b/pkgs/by-name/am/amoco/package.nix
@@ -7,7 +7,7 @@
 python3.pkgs.buildPythonApplication rec {
   pname = "amoco";
   version = "2.9.8";
-  format = "setuptools";
+  format = "pyproject";
 
   src = fetchFromGitHub {
     owner = "bdcht";
@@ -16,10 +16,11 @@ python3.pkgs.buildPythonApplication rec {
     hash = "sha256-3+1ssFyU7SKFJgDYBQY0kVjmTHOD71D2AjnH+4bfLXo=";
   };
 
-  nativeBuildInputs = with python3.pkgs; [
+  build-system = with python3.pkgs; [
+    setuptools
   ];
 
-  propagatedBuildInputs = with python3.pkgs; [
+  dependencies = with python3.pkgs; [
     blessed
     click
     crysp
diff --git a/pkgs/by-name/am/amphetype/package.nix b/pkgs/by-name/am/amphetype/package.nix
index 2b0de7c9dd1e..23d4c30edf8b 100644
--- a/pkgs/by-name/am/amphetype/package.nix
+++ b/pkgs/by-name/am/amphetype/package.nix
@@ -13,7 +13,7 @@ let
   description = "Advanced typing practice program";
 in
 python3Packages.buildPythonApplication {
-  format = "setuptools";
+  format = "pyproject";
   inherit pname version;
 
   src = fetchFromGitLab {
@@ -33,7 +33,11 @@ python3Packages.buildPythonApplication {
     qt5.qtwayland
   ];
 
-  propagatedBuildInputs = with python3Packages; [
+  build-system = with python3Packages; [
+    setuptools
+  ];
+
+  dependencies = with python3Packages; [
     editdistance
     pyqt5
     translitcodec
diff --git a/pkgs/by-name/an/antfs-cli/package.nix b/pkgs/by-name/an/antfs-cli/package.nix
index aa62577277d3..a5b11bc10bc8 100644
--- a/pkgs/by-name/an/antfs-cli/package.nix
+++ b/pkgs/by-name/an/antfs-cli/package.nix
@@ -7,7 +7,7 @@
 python3Packages.buildPythonApplication {
   pname = "antfs-cli";
   version = "unstable-2017-02-11";
-  format = "setuptools";
+  format = "pyproject";
 
   meta = with lib; {
     homepage = "https://github.com/Tigge/antfs-cli";
@@ -24,5 +24,7 @@ python3Packages.buildPythonApplication {
     sha256 = "0v8y64kldfbs809j1g9d75dd1vxq7mfxnp4b45pz8anpxhjf64fy";
   };
 
-  propagatedBuildInputs = [ python3Packages.openant ];
+  build-system = [ python3Packages.setuptools ];
+
+  dependencies = [ python3Packages.openant ];
 }
diff --git a/pkgs/by-name/ap/apksigcopier/package.nix b/pkgs/by-name/ap/apksigcopier/package.nix
index f2b5e0333c23..58ee87f22228 100644
--- a/pkgs/by-name/ap/apksigcopier/package.nix
+++ b/pkgs/by-name/ap/apksigcopier/package.nix
@@ -11,7 +11,7 @@
 python3.pkgs.buildPythonApplication rec {
   pname = "apksigcopier";
   version = "1.1.1";
-  format = "setuptools";
+  format = "pyproject";
 
   src = fetchFromGitHub {
     owner = "obfusk";
@@ -25,7 +25,11 @@ python3.pkgs.buildPythonApplication rec {
     pandoc
   ];
 
-  propagatedBuildInputs = with python3.pkgs; [
+  build-system = with python3.pkgs; [
+    setuptools
+  ];
+
+  dependencies = with python3.pkgs; [
     click
   ];
 
@@ -38,7 +42,7 @@ python3.pkgs.buildPythonApplication rec {
 
   postPatch = ''
     substituteInPlace Makefile \
-      --replace /bin/bash ${bash}/bin/bash
+      --replace-fail /bin/bash ${bash}/bin/bash
   '';
 
   postBuild = ''
diff --git a/pkgs/by-name/ap/apt-offline/package.nix b/pkgs/by-name/ap/apt-offline/package.nix
index 8d107e2e5dfb..a230ddaffe32 100644
--- a/pkgs/by-name/ap/apt-offline/package.nix
+++ b/pkgs/by-name/ap/apt-offline/package.nix
@@ -18,11 +18,15 @@ let
   };
 in
 python3Packages.buildPythonApplication {
-  format = "setuptools";
+  format = "pyproject";
   inherit pname version src;
 
   nativeBuildInputs = [ installShellFiles ];
 
+  build-system = with python3Packages; [
+    setuptools
+  ];
+
   postPatch = ''
     substituteInPlace org.debian.apt.aptoffline.policy \
       --replace-fail /usr/bin/ "$out/bin"
diff --git a/pkgs/by-name/ar/archivy/package.nix b/pkgs/by-name/ar/archivy/package.nix
index a61d6e267526..d653960ed152 100644
--- a/pkgs/by-name/ar/archivy/package.nix
+++ b/pkgs/by-name/ar/archivy/package.nix
@@ -22,21 +22,23 @@ let
     };
   };
 in
-with py.pkgs;
-
-buildPythonApplication rec {
+py.pkgs.buildPythonApplication rec {
   pname = "archivy";
   version = "1.7.3";
-  format = "setuptools";
+  format = "pyproject";
 
   src = fetchPypi {
     inherit pname version;
     hash = "sha256-ns1Y0DqqnTAQMEt+oBJ/P2gqKqPsX9P3/Z4561qzuns";
   };
 
+  build-system = with py.pkgs; [
+    setuptools
+  ];
+
   pythonRelaxDeps = true;
 
-  propagatedBuildInputs = [
+  dependencies = with py.pkgs; [
     appdirs
     attrs
     beautifulsoup4
@@ -50,7 +52,7 @@ buildPythonApplication rec {
     python-frontmatter
     readability-lxml
     requests
-    setuptools
+    setuptools # uses pkg_resources during runtime
     tinydb
     validators
     wtforms
diff --git a/pkgs/by-name/ar/arsenal/package.nix b/pkgs/by-name/ar/arsenal/package.nix
index a25e9aa232bc..1c15265cb443 100644
--- a/pkgs/by-name/ar/arsenal/package.nix
+++ b/pkgs/by-name/ar/arsenal/package.nix
@@ -7,7 +7,7 @@
 python3.pkgs.buildPythonApplication rec {
   pname = "arsenal";
   version = "1.1.0";
-  format = "setuptools";
+  format = "pyproject";
 
   src = fetchFromGitHub {
     owner = "Orange-Cyberdefense";
@@ -16,7 +16,11 @@ python3.pkgs.buildPythonApplication rec {
     sha256 = "sha256-NbNXyR5aNKvRJU9JWGk/ndwU1bhNgDOdcRqBkAY9nPA=";
   };
 
-  propagatedBuildInputs = with python3.pkgs; [
+  build-system = with python3.pkgs; [
+    setuptools
+  ];
+
+  dependencies = with python3.pkgs; [
     libtmux
     docutils
     pyfzf
diff --git a/pkgs/by-name/ar/arxiv-latex-cleaner/package.nix b/pkgs/by-name/ar/arxiv-latex-cleaner/package.nix
index b83f817089c0..83e7e96a662f 100644
--- a/pkgs/by-name/ar/arxiv-latex-cleaner/package.nix
+++ b/pkgs/by-name/ar/arxiv-latex-cleaner/package.nix
@@ -7,7 +7,7 @@
 python3Packages.buildPythonApplication rec {
   pname = "arxiv-latex-cleaner";
   version = "1.0.8";
-  format = "setuptools";
+  format = "pyproject";
 
   src = fetchFromGitHub {
     owner = "google-research";
@@ -16,7 +16,11 @@ python3Packages.buildPythonApplication rec {
     hash = "sha256-CQb1u1j+/px+vNqA3iXZ2oe6/0ZWeMjWrUQL9elRDEI=";
   };
 
-  propagatedBuildInputs = with python3Packages; [
+  build-system = with python3Packages; [
+    setuptools
+  ];
+
+  dependencies = with python3Packages; [
     pillow
     pyyaml
     regex
diff --git a/pkgs/by-name/as/asn1editor/package.nix b/pkgs/by-name/as/asn1editor/package.nix
index fa6c1c6bee9b..b3232610614e 100644
--- a/pkgs/by-name/as/asn1editor/package.nix
+++ b/pkgs/by-name/as/asn1editor/package.nix
@@ -7,7 +7,7 @@
 python3.pkgs.buildPythonApplication rec {
   pname = "asn1editor";
   version = "0.8.0";
-  format = "setuptools";
+  format = "pyproject";
 
   src = fetchFromGitHub {
     owner = "Futsch1";
@@ -16,7 +16,11 @@ python3.pkgs.buildPythonApplication rec {
     hash = "sha256-mgluhC2DMS4OyS/BoWqBdVf7GcxquOtOKTHZ/hbiHQM=";
   };
 
-  propagatedBuildInputs = with python3.pkgs; [
+  build-system = with python3.pkgs; [
+    setuptools
+  ];
+
+  dependencies = with python3.pkgs; [
     asn1tools
     coverage
     wxpython
diff --git a/pkgs/by-name/at/atomic-operator/package.nix b/pkgs/by-name/at/atomic-operator/package.nix
index 711bcdd7ce91..c289a06a56fb 100644
--- a/pkgs/by-name/at/atomic-operator/package.nix
+++ b/pkgs/by-name/at/atomic-operator/package.nix
@@ -7,7 +7,7 @@
 python3.pkgs.buildPythonApplication rec {
   pname = "atomic-operator";
   version = "0.8.5";
-  format = "setuptools";
+  format = "pyproject";
 
   src = fetchFromGitHub {
     owner = "swimlane";
@@ -16,12 +16,16 @@ python3.pkgs.buildPythonApplication rec {
     hash = "sha256-DyNqu3vndyLkmfybCfTbgxk3t/ALg7IAkAMg4kBkH7Q=";
   };
 
-  postPatch = ''
-    substituteInPlace setup.py \
-      --replace "charset_normalizer~=2.0.0" "charset_normalizer"
-  '';
+  build-system = with python3.pkgs; [
+    setuptools
+  ];
 
-  propagatedBuildInputs = with python3.pkgs; [
+  pythonRelaxDeps = [
+    "charset_normalizer"
+    "urllib3"
+  ];
+
+  dependencies = with python3.pkgs; [
     attrs
     certifi
     chardet
diff --git a/pkgs/by-name/au/autokey/package.nix b/pkgs/by-name/au/autokey/package.nix
index e6014bd53164..43779249f897 100644
--- a/pkgs/by-name/au/autokey/package.nix
+++ b/pkgs/by-name/au/autokey/package.nix
@@ -14,7 +14,7 @@
 python3Packages.buildPythonApplication rec {
   pname = "autokey";
   version = "0.96.0";
-  format = "setuptools";
+  format = "pyproject";
 
   src = fetchFromGitHub {
     owner = "autokey";
@@ -37,7 +37,11 @@ python3Packages.buildPythonApplication rec {
     libnotify
   ];
 
-  propagatedBuildInputs = with python3Packages; [
+  build-system = with python3Packages; [
+    setuptools
+  ];
+
+  dependencies = with python3Packages; [
     dbus-python
     pyinotify
     xlib
diff --git a/pkgs/by-name/ay/ayatana-webmail/package.nix b/pkgs/by-name/ay/ayatana-webmail/package.nix
index 93871340e426..a433a3985801 100644
--- a/pkgs/by-name/ay/ayatana-webmail/package.nix
+++ b/pkgs/by-name/ay/ayatana-webmail/package.nix
@@ -20,7 +20,7 @@
 python3Packages.buildPythonApplication rec {
   pname = "ayatana-webmail";
   version = "24.5.17";
-  format = "setuptools";
+  format = "pyproject";
 
   src = fetchFromGitHub {
     owner = "AyatanaIndicators";
@@ -53,7 +53,11 @@ python3Packages.buildPythonApplication rec {
     glib # For compiling gsettings-schemas
   ];
 
-  propagatedBuildInputs = with python3Packages; [
+  build-system = with python3Packages; [
+    setuptools
+  ];
+
+  dependencies = with python3Packages; [
     urllib3
     babel
     psutil
diff --git a/pkgs/by-name/ba/base16-shell-preview/package.nix b/pkgs/by-name/ba/base16-shell-preview/package.nix
index a376a364c1e4..a7a6dfcb11d1 100644
--- a/pkgs/by-name/ba/base16-shell-preview/package.nix
+++ b/pkgs/by-name/ba/base16-shell-preview/package.nix
@@ -10,7 +10,7 @@ let
 in
 python3Packages.buildPythonApplication {
   inherit pname version;
-  format = "setuptools";
+  format = "pyproject";
 
   src = fetchPypi {
     inherit version;
@@ -18,6 +18,10 @@ python3Packages.buildPythonApplication {
     hash = "sha256-UWS1weiccSGqBU8grPAUKkuXb7qs5wliHVaPgdW4KtI=";
   };
 
+  build-system = with python3Packages; [
+    setuptools
+  ];
+
   # If enabled, it will attempt to run '__init__.py, failing by trying to write
   # at "/homeless-shelter" as HOME
   doCheck = false;
diff --git a/pkgs/by-name/ba/bashplotlib/package.nix b/pkgs/by-name/ba/bashplotlib/package.nix
index cd5bd62e703d..afac32b49113 100644
--- a/pkgs/by-name/ba/bashplotlib/package.nix
+++ b/pkgs/by-name/ba/bashplotlib/package.nix
@@ -7,7 +7,7 @@
 python3Packages.buildPythonApplication {
   pname = "bashplotlib";
   version = "2021-03-31";
-  format = "setuptools";
+  format = "pyproject";
 
   src = fetchFromGitHub {
     owner = "glamp";
@@ -16,6 +16,10 @@ python3Packages.buildPythonApplication {
     sha256 = "sha256-0S6mgy6k7CcqsDR1kE5xcXGidF1t061e+M+ZuP2Gk3c=";
   };
 
+  build-system = with python3Packages; [
+    setuptools
+  ];
+
   # No tests
   doCheck = false;
 
diff --git a/pkgs/by-name/bk/bkyml/package.nix b/pkgs/by-name/bk/bkyml/package.nix
index 9f7dc8005bc3..ba1d5bdb2b44 100644
--- a/pkgs/by-name/bk/bkyml/package.nix
+++ b/pkgs/by-name/bk/bkyml/package.nix
@@ -4,12 +4,10 @@
   fetchPypi,
 }:
 
-with python3.pkgs;
-
-buildPythonApplication rec {
+python3.pkgs.buildPythonApplication rec {
   pname = "bkyml";
   version = "1.4.3";
-  format = "setuptools";
+  format = "pyproject";
 
   src = fetchPypi {
     inherit pname version;
@@ -21,24 +19,28 @@ buildPythonApplication rec {
   # of the package, that has been affected by the pyscaffold package dependency removal.
   postPatch = ''
     substituteInPlace setup.py \
-      --replace "['pyscaffold>=3.0a0,<3.1a0'] + " "" \
-      --replace "use_pyscaffold=True"  ""
-    substituteInPlace src/bkyml/skeleton.py --replace \
+      --replace-fail "['pyscaffold>=3.0a0,<3.1a0'] + " "" \
+      --replace-fail "use_pyscaffold=True"  ""
+    substituteInPlace src/bkyml/skeleton.py --replace-fail \
         "from bkyml import __version__" \
         "__version__ = \"${version}\""
   '';
 
+  build-system = with python3.pkgs; [
+    setuptools
+  ];
+
+  dependencies = with python3.pkgs; [
+    ruamel-yaml
+    setuptools
+  ];
+
   # Don't run tests because they are broken when run within
   # buildPythonApplication for reasons I don't quite understand.
   doCheck = false;
 
   pythonImportsCheck = [ "bkyml" ];
 
-  propagatedBuildInputs = [
-    ruamel-yaml
-    setuptools
-  ];
-
   meta = with lib; {
     homepage = "https://github.com/joscha/bkyml";
     description = "CLI tool to generate a pipeline.yaml file for Buildkite on the fly";
diff --git a/pkgs/by-name/bl/blivet-gui/package.nix b/pkgs/by-name/bl/blivet-gui/package.nix
index fca867456073..33076a5c27fb 100644
--- a/pkgs/by-name/bl/blivet-gui/package.nix
+++ b/pkgs/by-name/bl/blivet-gui/package.nix
@@ -22,7 +22,7 @@
 python3.pkgs.buildPythonApplication rec {
   pname = "blivet-gui";
   version = "2.6.0";
-  format = "setuptools";
+  format = "pyproject";
 
   src = fetchFromGitHub {
     owner = "storaged-project";
@@ -47,6 +47,10 @@ python3.pkgs.buildPythonApplication rec {
 
   buildInputs = [ gtk3 ];
 
+  build-system = [
+    python3.pkgs.setuptools
+  ];
+
   dependencies = [
     python3.pkgs.blivet
     python3.pkgs.pyparted
diff --git a/pkgs/by-name/br/brotab/package.nix b/pkgs/by-name/br/brotab/package.nix
index d91fafcaed13..3e86cba1efc2 100644
--- a/pkgs/by-name/br/brotab/package.nix
+++ b/pkgs/by-name/br/brotab/package.nix
@@ -8,7 +8,7 @@
 python3Packages.buildPythonApplication rec {
   pname = "brotab";
   version = "1.4.2";
-  format = "setuptools";
+  format = "pyproject";
 
   src = fetchFromGitHub {
     owner = "balta2ar";
@@ -26,7 +26,11 @@ python3Packages.buildPythonApplication rec {
     })
   ];
 
-  propagatedBuildInputs = with python3Packages; [
+  build-system = with python3Packages; [
+    setuptools
+  ];
+
+  dependencies = with python3Packages; [
     flask
     psutil
     requests
@@ -35,9 +39,9 @@ python3Packages.buildPythonApplication rec {
 
   postPatch = ''
     substituteInPlace requirements/base.txt \
-      --replace "Flask==2.0.2" "Flask>=2.0.2" \
-      --replace "psutil==5.8.0" "psutil>=5.8.0" \
-      --replace "requests==2.24.0" "requests>=2.24.0"
+      --replace-fail "Flask==2.0.2" "Flask>=2.0.2" \
+      --replace-fail "psutil==5.8.0" "psutil>=5.8.0" \
+      --replace-fail "requests==2.24.0" "requests>=2.24.0"
   '';
 
   __darwinAllowLocalNetworking = true;
diff --git a/pkgs/by-name/bt/btlejack/package.nix b/pkgs/by-name/bt/btlejack/package.nix
index dd96ae1b641e..e52449efef83 100644
--- a/pkgs/by-name/bt/btlejack/package.nix
+++ b/pkgs/by-name/bt/btlejack/package.nix
@@ -7,7 +7,7 @@
 python3Packages.buildPythonApplication rec {
   pname = "btlejack";
   version = "2.1.1";
-  format = "setuptools";
+  format = "pyproject";
 
   src = fetchFromGitHub {
     owner = "virtualabs";
@@ -20,7 +20,11 @@ python3Packages.buildPythonApplication rec {
     sed -i "s|^.*'argparse',$||" setup.py
   '';
 
-  propagatedBuildInputs = [
+  build-system = [
+    python3Packages.setuptools
+  ];
+
+  dependencies = [
     python3Packages.pyserial
     python3Packages.halo
   ];
diff --git a/pkgs/by-name/bu/bubblemail/package.nix b/pkgs/by-name/bu/bubblemail/package.nix
index 5ceb16b116b0..cf05f04a0fb5 100644
--- a/pkgs/by-name/bu/bubblemail/package.nix
+++ b/pkgs/by-name/bu/bubblemail/package.nix
@@ -20,7 +20,7 @@
 python3Packages.buildPythonApplication rec {
   pname = "bubblemail";
   version = "1.9";
-  format = "setuptools";
+  format = "pyproject";
 
   src = fetchFromGitLab {
     domain = "framagit.org";
@@ -53,6 +53,10 @@ python3Packages.buildPythonApplication rec {
     gobject-introspection
   ];
 
+  build-system = with python3Packages; [
+    setuptools
+  ];
+
   propagatedBuildInputs = with python3Packages; [
     gsettings-desktop-schemas
     pygobject3
diff --git a/pkgs/by-name/bu/bumblebee-status/package.nix b/pkgs/by-name/bu/bumblebee-status/package.nix
index 83cca48c1a9b..0b900a17ad3c 100644
--- a/pkgs/by-name/bu/bumblebee-status/package.nix
+++ b/pkgs/by-name/bu/bumblebee-status/package.nix
@@ -22,7 +22,7 @@ in
 python3.pkgs.buildPythonPackage {
   pname = "bumblebee-status";
   inherit version;
-  format = "setuptools";
+  format = "pyproject";
 
   src = fetchFromGitHub {
     owner = "tobi-wan-kenobi";
@@ -40,10 +40,15 @@ python3.pkgs.buildPythonPackage {
     })
   ];
 
+  build-system = with python3.pkgs; [
+    setuptools
+  ];
+
   buildInputs = lib.concatMap (p: p.buildInputs or [ ]) selectedPlugins;
+
   propagatedBuildInputs = lib.concatMap (p: p.propagatedBuildInputs or [ ]) selectedPlugins;
 
-  checkInputs = with python3.pkgs; [
+  nativeCheckInputs = with python3.pkgs; [
     freezegun
     netifaces
     psutil
diff --git a/pkgs/by-name/bu/bumpver/package.nix b/pkgs/by-name/bu/bumpver/package.nix
index 41da92091a92..5d3c6b531fbb 100644
--- a/pkgs/by-name/bu/bumpver/package.nix
+++ b/pkgs/by-name/bu/bumpver/package.nix
@@ -9,7 +9,7 @@
 python3.pkgs.buildPythonApplication rec {
   pname = "bumpver";
   version = "2021.1110";
-  format = "setuptools";
+  format = "pyproject";
 
   src = fetchPypi {
     inherit pname version;
@@ -18,12 +18,16 @@ python3.pkgs.buildPythonApplication rec {
 
   prePatch = ''
     substituteInPlace setup.py \
-      --replace "if any(arg.startswith(\"bdist\") for arg in sys.argv):" ""\
-      --replace "import lib3to6" ""\
-      --replace "package_dir = lib3to6.fix(package_dir)" ""
+      --replace-fail "if any(arg.startswith(\"bdist\") for arg in sys.argv):" ""\
+      --replace-fail "import lib3to6" ""\
+      --replace-fail "package_dir = lib3to6.fix(package_dir)" ""
   '';
 
-  propagatedBuildInputs = with python3.pkgs; [
+  build-system = with python3.pkgs; [
+    setuptools
+  ];
+
+  dependencies = with python3.pkgs; [
     pathlib2
     click
     toml
diff --git a/pkgs/by-name/ca/canto-curses/package.nix b/pkgs/by-name/ca/canto-curses/package.nix
index e0a3d12cd011..06ba2e88c00c 100644
--- a/pkgs/by-name/ca/canto-curses/package.nix
+++ b/pkgs/by-name/ca/canto-curses/package.nix
@@ -10,7 +10,7 @@
 
 python3Packages.buildPythonApplication rec {
   version = "0.9.9";
-  format = "setuptools";
+  format = "pyproject";
   pname = "canto-curses";
 
   src = fetchFromGitHub {
@@ -28,6 +28,10 @@ python3Packages.buildPythonApplication rec {
     })
   ];
 
+  build-system = with python3Packages; [
+    setuptools
+  ];
+
   buildInputs = [
     readline
     ncurses
diff --git a/pkgs/by-name/ca/canto-daemon/package.nix b/pkgs/by-name/ca/canto-daemon/package.nix
index bd6cedb2c64e..d02fd492273f 100644
--- a/pkgs/by-name/ca/canto-daemon/package.nix
+++ b/pkgs/by-name/ca/canto-daemon/package.nix
@@ -6,7 +6,7 @@
 
 python3Packages.buildPythonApplication rec {
   version = "0.9.8";
-  format = "setuptools";
+  format = "pyproject";
   pname = "canto-daemon";
 
   src = fetchFromGitHub {
@@ -16,7 +16,9 @@ python3Packages.buildPythonApplication rec {
     sha256 = "0fmsdn28z09bvivdkqcla5bnalky7k744iir25z70bv4pz1jcvnk";
   };
 
-  propagatedBuildInputs = with python3Packages; [ feedparser ];
+  build-system = with python3Packages; [ setuptools ];
+
+  dependencies = with python3Packages; [ feedparser ];
 
   doCheck = false;
 
diff --git a/pkgs/by-name/ca/cantoolz/package.nix b/pkgs/by-name/ca/cantoolz/package.nix
index 8269a91eb982..7f911f9001cd 100644
--- a/pkgs/by-name/ca/cantoolz/package.nix
+++ b/pkgs/by-name/ca/cantoolz/package.nix
@@ -8,7 +8,7 @@
 python3.pkgs.buildPythonApplication rec {
   pname = "cantoolz";
   version = "3.7.0";
-  format = "setuptools";
+  format = "pyproject";
 
   src = fetchFromGitHub {
     owner = "CANToolz";
@@ -30,7 +30,11 @@ python3.pkgs.buildPythonApplication rec {
     })
   ];
 
-  propagatedBuildInputs = with python3.pkgs; [
+  build-system = with python3.pkgs; [
+    setuptools
+  ];
+
+  dependencies = with python3.pkgs; [
     flask
     pyserial
     mido
diff --git a/pkgs/by-name/ch/charge-lnd/package.nix b/pkgs/by-name/ch/charge-lnd/package.nix
index 33b3cb5d0f06..bf32c78a05fd 100644
--- a/pkgs/by-name/ch/charge-lnd/package.nix
+++ b/pkgs/by-name/ch/charge-lnd/package.nix
@@ -8,7 +8,7 @@
 python3Packages.buildPythonApplication rec {
   pname = "charge-lnd";
   version = "0.3.0";
-  format = "setuptools";
+  format = "pyproject";
 
   src = fetchFromGitHub {
     owner = "accumulator";
@@ -17,6 +17,10 @@ python3Packages.buildPythonApplication rec {
     hash = "sha256-a/zIEA2oF1+BoZXk4YDWx69eVFSnANUE/F+ARI/VsXU=";
   };
 
+  build-system = with python3Packages; [
+    setuptools
+  ];
+
   propagatedBuildInputs = with python3Packages; [
     aiorpcx
     colorama
diff --git a/pkgs/by-name/ch/chatblade/package.nix b/pkgs/by-name/ch/chatblade/package.nix
index 3e360e95dca7..50cef1df9416 100644
--- a/pkgs/by-name/ch/chatblade/package.nix
+++ b/pkgs/by-name/ch/chatblade/package.nix
@@ -7,7 +7,7 @@
 python3Packages.buildPythonApplication rec {
   pname = "chatblade";
   version = "0.7.0";
-  format = "setuptools";
+  format = "pyproject";
 
   src = fetchPypi {
     inherit pname version;
@@ -17,7 +17,14 @@ python3Packages.buildPythonApplication rec {
   doCheck = false; # there are no tests
 
   pythonImportsCheck = [ "chatblade" ];
-  propagatedBuildInputs = with python3Packages; [
+
+  build-system = with python3Packages; [
+    setuptools
+  ];
+
+  pythonRelaxDeps = true;
+
+  dependencies = with python3Packages; [
     openai
     platformdirs
     pylatexenc
diff --git a/pkgs/by-name/cl/clickable/package.nix b/pkgs/by-name/cl/clickable/package.nix
index 1b10ec53dee3..e0f088ccd88c 100644
--- a/pkgs/by-name/cl/clickable/package.nix
+++ b/pkgs/by-name/cl/clickable/package.nix
@@ -9,7 +9,7 @@
 python3Packages.buildPythonApplication rec {
   pname = "clickable";
   version = "8.3.1";
-  format = "setuptools";
+  format = "pyproject";
 
   src = fetchFromGitLab {
     owner = "clickable";
@@ -18,7 +18,9 @@ python3Packages.buildPythonApplication rec {
     hash = "sha256-Vn2PyALaRrE+jJRdZzW+jjCm3f2GfpgrQcFGB7kr4EM=";
   };
 
-  propagatedBuildInputs = with python3Packages; [
+  build-system = [ python3Packages.setuptools ];
+
+  dependencies = with python3Packages; [
     cookiecutter
     requests
     pyyaml
diff --git a/pkgs/by-name/co/colorz/package.nix b/pkgs/by-name/co/colorz/package.nix
index b93e88c76fde..9956ba8a782f 100644
--- a/pkgs/by-name/co/colorz/package.nix
+++ b/pkgs/by-name/co/colorz/package.nix
@@ -7,14 +7,18 @@
 python3Packages.buildPythonApplication rec {
   pname = "colorz";
   version = "1.0.3";
-  format = "setuptools";
+  format = "pyproject";
 
   src = fetchPypi {
     inherit pname version;
     sha256 = "0ghd90lgplf051fs5n5bb42zffd3fqpgzkbv6bhjw7r8jqwgcky0";
   };
 
-  propagatedBuildInputs = with python3Packages; [
+  build-system = with python3Packages; [
+    setuptools
+  ];
+
+  dependencies = with python3Packages; [
     pillow
     scipy
   ];
diff --git a/pkgs/by-name/co/compdb/package.nix b/pkgs/by-name/co/compdb/package.nix
index 3fdb64236fc2..03ef026bb094 100644
--- a/pkgs/by-name/co/compdb/package.nix
+++ b/pkgs/by-name/co/compdb/package.nix
@@ -7,7 +7,7 @@
 python3.pkgs.buildPythonApplication rec {
   pname = "compdb";
   version = "0.2.0";
-  format = "setuptools";
+  format = "pyproject";
 
   src = fetchFromGitHub {
     owner = "Sarcasm";
@@ -16,6 +16,10 @@ python3.pkgs.buildPythonApplication rec {
     sha256 = "sha256-nFAgTrup6V5oE+LP4UWDOCgTVCv2v9HbQbkGW+oDnTg=";
   };
 
+  build-system = with python3.pkgs; [
+    setuptools
+  ];
+
   meta = with lib; {
     description = "Command line tool to manipulate compilation databases";
     license = licenses.mit;
diff --git a/pkgs/by-name/cp/cp210x-program/package.nix b/pkgs/by-name/cp/cp210x-program/package.nix
index 3c61333b0c9a..2e41daf44f14 100644
--- a/pkgs/by-name/cp/cp210x-program/package.nix
+++ b/pkgs/by-name/cp/cp210x-program/package.nix
@@ -7,7 +7,7 @@
 python3.pkgs.buildPythonApplication rec {
   pname = "cp210x-program";
   version = "0.4.1";
-  format = "setuptools";
+  format = "pyproject";
 
   src = fetchFromGitHub {
     owner = "VCTLabs";
@@ -16,7 +16,11 @@ python3.pkgs.buildPythonApplication rec {
     sha256 = "sha256-IjKshP12WfFly9cPm6svD4qZW6cT8C7lOVrGenSqbfY=";
   };
 
-  propagatedBuildInputs = with python3.pkgs; [
+  build-system = with python3.pkgs; [
+    setuptools
+  ];
+
+  dependencies = with python3.pkgs; [
     hexdump
     pyusb
   ];
diff --git a/pkgs/by-name/cp/cppclean/package.nix b/pkgs/by-name/cp/cppclean/package.nix
index 7437e65a0848..561793b61463 100644
--- a/pkgs/by-name/cp/cppclean/package.nix
+++ b/pkgs/by-name/cp/cppclean/package.nix
@@ -4,12 +4,10 @@
   python3Packages,
 }:
 
-with python3Packages;
-
-buildPythonApplication rec {
+python3Packages.buildPythonApplication rec {
   pname = "cppclean";
   version = "0.13";
-  format = "setuptools";
+  format = "pyproject";
 
   src = fetchFromGitHub {
     owner = "myint";
@@ -22,6 +20,10 @@ buildPythonApplication rec {
     patchShebangs .
   '';
 
+  build-system = with python3Packages; [
+    setuptools
+  ];
+
   checkPhase = ''
     ./test.bash
   '';
diff --git a/pkgs/by-name/cp/cpuset/package.nix b/pkgs/by-name/cp/cpuset/package.nix
index 1aa016a8f6df..6dff3c9f53bd 100644
--- a/pkgs/by-name/cp/cpuset/package.nix
+++ b/pkgs/by-name/cp/cpuset/package.nix
@@ -7,7 +7,7 @@
 python3.pkgs.buildPythonApplication rec {
   pname = "cpuset";
   version = "1.6.2";
-  format = "setuptools";
+  format = "pyproject";
 
   src = fetchFromGitHub {
     owner = "lpechacek";
@@ -16,6 +16,10 @@ python3.pkgs.buildPythonApplication rec {
     hash = "sha256-fW0SXNI10pb6FTn/2TOqxP9qlys0KL/H9m//NjslUaY=";
   };
 
+  build-system = with python3.pkgs; [
+    setuptools
+  ];
+
   makeFlags = [ "prefix=$(out)" ];
 
   checkPhase = ''
diff --git a/pkgs/by-name/cr/creds/package.nix b/pkgs/by-name/cr/creds/package.nix
index 797f3737e133..68fb8fd0da0f 100644
--- a/pkgs/by-name/cr/creds/package.nix
+++ b/pkgs/by-name/cr/creds/package.nix
@@ -7,7 +7,7 @@
 python3.pkgs.buildPythonApplication rec {
   pname = "creds";
   version = "0.5.3";
-  format = "setuptools";
+  format = "pyproject";
 
   src = fetchFromGitHub {
     owner = "ihebski";
@@ -21,10 +21,14 @@ python3.pkgs.buildPythonApplication rec {
 
   postPatch = ''
     substituteInPlace creds \
-      --replace "pathlib.Path(__file__).parent" "pathlib.Path.home()"
+      --replace-fail "pathlib.Path(__file__).parent" "pathlib.Path.home()"
   '';
 
-  propagatedBuildInputs = with python3.pkgs; [
+  build-system = with python3.pkgs; [
+    setuptools
+  ];
+
+  dependencies = with python3.pkgs; [
     fire
     prettytable
     requests
diff --git a/pkgs/by-name/cr/crlfsuite/package.nix b/pkgs/by-name/cr/crlfsuite/package.nix
index dadb9067590f..a4a493bc9c82 100644
--- a/pkgs/by-name/cr/crlfsuite/package.nix
+++ b/pkgs/by-name/cr/crlfsuite/package.nix
@@ -7,7 +7,7 @@
 python3.pkgs.buildPythonApplication rec {
   pname = "crlfsuite";
   version = "2.5.2";
-  format = "setuptools";
+  format = "pyproject";
 
   src = fetchFromGitHub {
     owner = "Nefcore";
@@ -16,7 +16,11 @@ python3.pkgs.buildPythonApplication rec {
     sha256 = "sha256-mK20PbVGhTEjhY5L6coCzSMIrG/PHHmNq30ZoJEs6uI=";
   };
 
-  propagatedBuildInputs = with python3.pkgs; [
+  build-system = with python3.pkgs; [
+    setuptools
+  ];
+
+  dependencies = with python3.pkgs; [
     colorama
     requests
   ];
diff --git a/pkgs/by-name/cr/crowbar/package.nix b/pkgs/by-name/cr/crowbar/package.nix
index ed2911bb5b66..a70ad5032a5f 100644
--- a/pkgs/by-name/cr/crowbar/package.nix
+++ b/pkgs/by-name/cr/crowbar/package.nix
@@ -11,7 +11,7 @@
 python3Packages.buildPythonApplication {
   pname = "crowbar";
   version = "unstable-2020-04-23";
-  format = "setuptools";
+  format = "pyproject";
 
   src = fetchFromGitHub {
     owner = "galkan";
@@ -20,7 +20,9 @@ python3Packages.buildPythonApplication {
     sha256 = "05m9vywr9976pc7il0ak8nl26mklzxlcqx0p8rlfyx1q766myqzf";
   };
 
-  propagatedBuildInputs = [ python3Packages.paramiko ];
+  build-system = [ python3Packages.setuptools ];
+
+  dependencies = [ python3Packages.paramiko ];
 
   patchPhase = ''
     sed -i 's,/usr/bin/xfreerdp,${freerdp}/bin/xfreerdp,g' lib/main.py
diff --git a/pkgs/by-name/cs/csv2odf/package.nix b/pkgs/by-name/cs/csv2odf/package.nix
index 9119b697c30e..50643f2c2c17 100644
--- a/pkgs/by-name/cs/csv2odf/package.nix
+++ b/pkgs/by-name/cs/csv2odf/package.nix
@@ -7,12 +7,17 @@
 python3.pkgs.buildPythonApplication rec {
   pname = "csv2odf";
   version = "2.09";
-  format = "setuptools";
+  format = "pyproject";
+
   src = fetchurl {
     url = "mirror://sourceforge/project/${pname}/${pname}-${version}/${pname}-${version}.tar.gz";
     sha256 = "09l0yfay89grjdzap2h11f0hcyn49np5zizg2yyp2aqgjs8ki57p";
   };
 
+  build-system = with python3.pkgs; [
+    setuptools
+  ];
+
   meta = with lib; {
     homepage = "https://sourceforge.net/p/csv2odf/wiki/Main_Page/";
     description = "Convert csv files to OpenDocument Format";
diff --git a/pkgs/by-name/cs/csvs-to-sqlite/package.nix b/pkgs/by-name/cs/csvs-to-sqlite/package.nix
index c054aa2f2301..796b0a558f84 100644
--- a/pkgs/by-name/cs/csvs-to-sqlite/package.nix
+++ b/pkgs/by-name/cs/csvs-to-sqlite/package.nix
@@ -5,11 +5,10 @@
   fetchpatch,
 }:
 
-with python3.pkgs;
-buildPythonApplication rec {
+python3.pkgs.buildPythonApplication rec {
   pname = "csvs-to-sqlite";
   version = "1.3";
-  format = "setuptools";
+  format = "pyproject";
 
   src = fetchFromGitHub {
     owner = "simonw";
@@ -32,10 +31,11 @@ buildPythonApplication rec {
     })
   ];
 
-  nativeBuildInputs = [
+  build-system = with python3.pkgs; [
+    setuptools
   ];
 
-  propagatedBuildInputs = [
+  dependencies = with python3.pkgs; [
     click
     dateparser
     pandas
@@ -47,7 +47,7 @@ buildPythonApplication rec {
     "click"
   ];
 
-  nativeCheckInputs = [
+  nativeCheckInputs = with python3.pkgs; [
     cogapp
     pytestCheckHook
   ];
diff --git a/pkgs/by-name/cu/cum/package.nix b/pkgs/by-name/cu/cum/package.nix
index 98e055250f79..f14e48dc8a70 100644
--- a/pkgs/by-name/cu/cum/package.nix
+++ b/pkgs/by-name/cu/cum/package.nix
@@ -4,19 +4,21 @@
   fetchPypi,
 }:
 
-with python3Packages;
-
-buildPythonApplication rec {
+python3Packages.buildPythonApplication rec {
   pname = "cum";
   version = "0.9.1";
-  format = "setuptools";
+  format = "pyproject";
 
   src = fetchPypi {
     inherit pname version;
     sha256 = "15qc6agka2g3kcnpnz0hbjic1s3260cr9bda0rlcyninxs1vndq0";
   };
 
-  propagatedBuildInputs = [
+  build-system = with python3Packages; [
+    setuptools
+  ];
+
+  dependencies = with python3Packages; [
     alembic
     beautifulsoup4
     click
diff --git a/pkgs/by-name/cu/curseradio/package.nix b/pkgs/by-name/cu/curseradio/package.nix
index 8c97d7620dd0..6449e00ed35b 100644
--- a/pkgs/by-name/cu/curseradio/package.nix
+++ b/pkgs/by-name/cu/curseradio/package.nix
@@ -8,7 +8,7 @@
 
 python3Packages.buildPythonApplication {
   version = "0.2";
-  format = "setuptools";
+  format = "pyproject";
   pname = "curseradio";
 
   src = fetchFromGitHub {
@@ -18,7 +18,11 @@ python3Packages.buildPythonApplication {
     sha256 = "11bf0jnj8h2fxhpdp498189r4s6b47vy4wripv0z4nx7lxajl88i";
   };
 
-  propagatedBuildInputs = with python3Packages; [
+  build-system = with python3Packages; [
+    setuptools
+  ];
+
+  dependencies = with python3Packages; [
     requests
     lxml
     pyxdg
diff --git a/pkgs/by-name/cu/cursewords/package.nix b/pkgs/by-name/cu/cursewords/package.nix
index e30b672901c9..dced1f5e345b 100644
--- a/pkgs/by-name/cu/cursewords/package.nix
+++ b/pkgs/by-name/cu/cursewords/package.nix
@@ -6,7 +6,7 @@
 python3Packages.buildPythonApplication rec {
   pname = "cursewords";
   version = "1.1";
-  format = "setuptools";
+  format = "pyproject";
 
   src = fetchFromGitHub {
     owner = "thisisparker";
@@ -15,14 +15,17 @@ python3Packages.buildPythonApplication rec {
     hash = "sha256-Ssr15kSdWmyMFFG5uCregrpGQ3rI2cMXqY9+/a3gs84=";
   };
 
-  nativeBuildInputs = [
+  build-system = [
     python3Packages.setuptools
-    python3Packages.wheel
   ];
 
   doCheck = false; # no tests
 
-  propagatedBuildInputs = [
+  pythonRelaxDeps = [
+    "blessed"
+  ];
+
+  dependencies = [
     python3Packages.blessed
   ];
 
diff --git a/pkgs/by-name/cv/cvehound/package.nix b/pkgs/by-name/cv/cvehound/package.nix
index 3103087c5c53..8a0a86da2244 100644
--- a/pkgs/by-name/cv/cvehound/package.nix
+++ b/pkgs/by-name/cv/cvehound/package.nix
@@ -9,7 +9,7 @@
 python3.pkgs.buildPythonApplication rec {
   pname = "cvehound";
   version = "1.2.1";
-  format = "setuptools";
+  format = "pyproject";
 
   src = fetchFromGitHub {
     owner = "evdenis";
@@ -27,9 +27,12 @@ python3.pkgs.buildPythonApplication rec {
     }"
   ];
 
-  propagatedBuildInputs = with python3.pkgs; [
-    lxml
+  build-system = with python3.pkgs; [
     setuptools
+  ];
+
+  dependencies = with python3.pkgs; [
+    lxml
     sympy
   ];
 
diff --git a/pkgs/by-name/di/dict-cc-py/package.nix b/pkgs/by-name/di/dict-cc-py/package.nix
index c13d23af1ef8..9c573b035e7a 100644
--- a/pkgs/by-name/di/dict-cc-py/package.nix
+++ b/pkgs/by-name/di/dict-cc-py/package.nix
@@ -7,7 +7,7 @@
 python3.pkgs.buildPythonPackage {
   pname = "dict.cc.py";
   version = "3.1.0";
-  format = "setuptools";
+  format = "pyproject";
 
   src = fetchFromGitHub {
     owner = "rbaron";
@@ -16,7 +16,11 @@ python3.pkgs.buildPythonPackage {
     hash = "sha256-wc0WY1pETBdOT3QUaVGsX8YdcnhxLIHrZ2vt2t5LYKU=";
   };
 
-  propagatedBuildInputs = with python3.pkgs; [
+  build-system = with python3.pkgs; [
+    setuptools
+  ];
+
+  dependencies = with python3.pkgs; [
     beautifulsoup4
     colorama
     requests
diff --git a/pkgs/by-name/dn/dnd-tools/package.nix b/pkgs/by-name/dn/dnd-tools/package.nix
index 80aa0a9c5856..419a5e81e3d2 100644
--- a/pkgs/by-name/dn/dnd-tools/package.nix
+++ b/pkgs/by-name/dn/dnd-tools/package.nix
@@ -8,7 +8,7 @@
 python3.pkgs.buildPythonApplication {
   pname = "dnd-tools";
   version = "unstable-2021-02-18";
-  format = "setuptools";
+  format = "pyproject";
 
   src = fetchFromGitHub {
     owner = "savagezen";
@@ -25,6 +25,10 @@ python3.pkgs.buildPythonApplication {
     })
   ];
 
+  build-system = with python3.pkgs; [
+    setuptools
+  ];
+
   meta = with lib; {
     homepage = "https://github.com/savagezen/dnd-tools";
     description = "Set of interactive command line tools for Dungeons and Dragons 5th Edition";
diff --git a/pkgs/by-name/dn/dnsviz/package.nix b/pkgs/by-name/dn/dnsviz/package.nix
index 81d3d42df88d..ffc23789d370 100644
--- a/pkgs/by-name/dn/dnsviz/package.nix
+++ b/pkgs/by-name/dn/dnsviz/package.nix
@@ -7,7 +7,7 @@
 python3Packages.buildPythonApplication rec {
   pname = "dnsviz";
   version = "0.11.1";
-  format = "setuptools";
+  format = "pyproject";
 
   src = fetchFromGitHub {
     owner = "dnsviz";
@@ -26,6 +26,10 @@ python3Packages.buildPythonApplication rec {
       --replace-fail '@out@' $out
   '';
 
+  build-system = with python3Packages; [
+    setuptools
+  ];
+
   dependencies = with python3Packages; [
     dnspython
     m2crypto
diff --git a/pkgs/by-name/do/dockbarx/package.nix b/pkgs/by-name/do/dockbarx/package.nix
index 19e56c3f4b10..66e87de70cf5 100644
--- a/pkgs/by-name/do/dockbarx/package.nix
+++ b/pkgs/by-name/do/dockbarx/package.nix
@@ -13,7 +13,7 @@
 python3Packages.buildPythonApplication rec {
   pname = "dockbarx";
   version = "1.0-beta4";
-  format = "setuptools";
+  format = "pyproject";
 
   src = fetchFromGitHub {
     owner = "xuzhen";
@@ -35,7 +35,11 @@ python3Packages.buildPythonApplication rec {
     keybinder3
   ];
 
-  propagatedBuildInputs = with python3Packages; [
+  build-system = with python3Packages; [
+    setuptools
+  ];
+
+  dependencies = with python3Packages; [
     dbus-python
     pillow
     pygobject3
diff --git a/pkgs/by-name/do/dotfiles/package.nix b/pkgs/by-name/do/dotfiles/package.nix
index 9a4dda3a4952..2ff9168c131c 100644
--- a/pkgs/by-name/do/dotfiles/package.nix
+++ b/pkgs/by-name/do/dotfiles/package.nix
@@ -7,7 +7,7 @@
 python3Packages.buildPythonApplication rec {
   pname = "dotfiles";
   version = "0.6.5";
-  format = "setuptools";
+  format = "pyproject";
 
   src = fetchPypi {
     inherit version pname;
@@ -17,8 +17,11 @@ python3Packages.buildPythonApplication rec {
   # No tests in archive
   doCheck = false;
 
+  build-system = with python3Packages; [ setuptools ];
+
+  dependencies = with python3Packages; [ click ];
+
   nativeCheckInputs = with python3Packages; [ pytest ];
-  propagatedBuildInputs = with python3Packages; [ click ];
 
   meta = with lib; {
     description = "Easily manage your dotfiles";
diff --git a/pkgs/by-name/dp/dpt-rp1-py/package.nix b/pkgs/by-name/dp/dpt-rp1-py/package.nix
index e8b0d2c255af..e3b1f84af9b0 100644
--- a/pkgs/by-name/dp/dpt-rp1-py/package.nix
+++ b/pkgs/by-name/dp/dpt-rp1-py/package.nix
@@ -6,7 +6,7 @@
 python3Packages.buildPythonApplication rec {
   pname = "dpt-rp1-py";
   version = "0.1.16";
-  format = "setuptools";
+  format = "pyproject";
 
   src = fetchFromGitHub {
     owner = "janten";
@@ -17,14 +17,17 @@ python3Packages.buildPythonApplication rec {
 
   doCheck = false;
 
-  propagatedBuildInputs = with python3Packages; [
+  build-system = with python3Packages; [
+    setuptools
+  ];
+
+  dependencies = with python3Packages; [
     anytree
     fusepy
     httpsig
     pbkdf2
     pyyaml
     requests
-    setuptools
     tqdm
     urllib3
     zeroconf
diff --git a/pkgs/by-name/dt/dtrx/package.nix b/pkgs/by-name/dt/dtrx/package.nix
index 7315e382ea32..d0c743357174 100644
--- a/pkgs/by-name/dt/dtrx/package.nix
+++ b/pkgs/by-name/dt/dtrx/package.nix
@@ -24,7 +24,7 @@
 python3Packages.buildPythonApplication rec {
   pname = "dtrx";
   version = "8.5.3";
-  format = "setuptools";
+  format = "pyproject";
 
   src = fetchFromGitHub {
     owner = "dtrx-py";
@@ -58,7 +58,9 @@ python3Packages.buildPythonApplication rec {
       ''--prefix PATH : "${archivers}"''
     ];
 
-  nativeBuildInputs = [ python3Packages.invoke ];
+  build-system = with python3Packages; [
+    setuptools
+  ];
 
   passthru.updateScript = gitUpdater { };