diff --git a/pkgs/development/python-modules/pyequihash/default.nix b/pkgs/development/python-modules/pyequihash/default.nix
new file mode 100644
index 000000000000..54b033d2b89e
--- /dev/null
+++ b/pkgs/development/python-modules/pyequihash/default.nix
@@ -0,0 +1,50 @@
+{
+  lib,
+  stdenv,
+  buildPythonPackage,
+  equihash,
+  setuptools,
+  python,
+}:
+
+buildPythonPackage rec {
+  pname = "pyequihash";
+  pyproject = true;
+
+  inherit (equihash)
+    version
+    src
+    ;
+
+  sourceRoot = "${src.name}/python";
+
+  postPatch =
+    let
+      soext = stdenv.hostPlatform.extensions.sharedLibrary;
+    in
+    ''
+      substituteInPlace ./equihash/__init__.py --replace-fail \
+        "ctypes.util.find_library('equihash') or ctypes.util.find_library('libequihash')" "'${lib.getLib equihash}/lib/libequihash${soext}'"
+    '';
+
+  build-system = [ setuptools ];
+
+  pythonImportsCheck = [ "equihash" ];
+
+  checkPhase = ''
+    runHook preCheck
+
+    ${python.interpreter} test.py
+
+    runHook postCheck
+  '';
+
+  meta = {
+    inherit (equihash.meta)
+      description
+      homepage
+      license
+      teams
+      ;
+  };
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 19828a5367b9..63f34f2743bf 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -12777,6 +12777,8 @@ self: super: with self; {
 
   pyepsg = callPackage ../development/python-modules/pyepsg { };
 
+  pyequihash = callPackage ../development/python-modules/pyequihash { };
+
   pyerfa = callPackage ../development/python-modules/pyerfa { };
 
   pyeverlights = callPackage ../development/python-modules/pyeverlights { };