diff --git a/pkgs/applications/radio/gnuradio/default.nix b/pkgs/applications/radio/gnuradio/default.nix
index f376fe9e5061..96962f914f7a 100644
--- a/pkgs/applications/radio/gnuradio/default.nix
+++ b/pkgs/applications/radio/gnuradio/default.nix
@@ -67,7 +67,7 @@ let
       # when gr-qtgui is disabled, icu needs to be included, otherwise
       # building with boost 1.7x fails
       ++ lib.optionals (!(hasFeature "gr-qtgui")) [ icu ];
-      pythonNative = with python.pkgs; [
+      pythonNative = with python.pythonOnBuildForHost.pkgs; [
         mako
         six
       ];
@@ -337,6 +337,8 @@ stdenv.mkDerivation (
         # This is the only python reference worth removing, if needed.
         + lib.optionalString (!hasFeature "python-support") ''
           remove-references-to -t ${python} $out/lib/cmake/gnuradio/GnuradioConfig.cmake
+        ''
+        + lib.optionalString (!hasFeature "python-support" && hasFeature "gnuradio-runtime") ''
           remove-references-to -t ${python} $(readlink -f $out/lib/libgnuradio-runtime${stdenv.hostPlatform.extensions.sharedLibrary})
           remove-references-to -t ${python.pkgs.pybind11} $out/lib/cmake/gnuradio/gnuradio-runtimeTargets.cmake
         '';
diff --git a/pkgs/applications/radio/gnuradio/shared.nix b/pkgs/applications/radio/gnuradio/shared.nix
index 0488393bc989..3eac7df05476 100644
--- a/pkgs/applications/radio/gnuradio/shared.nix
+++ b/pkgs/applications/radio/gnuradio/shared.nix
@@ -24,6 +24,7 @@ let
     minor = builtins.elemAt (lib.splitVersion version) 2;
     patch = builtins.elemAt (lib.splitVersion version) 3;
   };
+  cross = stdenv.hostPlatform != stdenv.buildPlatform;
 in
 {
   src =
@@ -53,26 +54,30 @@ in
       feat: info:
       (lib.optionals (hasFeature feat) (
         (lib.optionals (builtins.hasAttr "runtime" info) info.runtime)
-        ++ (lib.optionals (builtins.hasAttr "pythonRuntime" info) info.pythonRuntime)
+        ++ (lib.optionals (
+          builtins.hasAttr "pythonRuntime" info && hasFeature "python-support"
+        ) info.pythonRuntime)
       ))
     ) featuresInfo
   );
-  cmakeFlags = lib.mapAttrsToList (
+  cmakeFlags = [
+    # https://pybind11.readthedocs.io/en/stable/changelog.html#version-2-13-0-june-25-2024
+    (lib.cmakeBool "CMAKE_CROSSCOMPILING" cross)
+    (lib.cmakeBool "PYBIND11_USE_CROSSCOMPILING" (cross && hasFeature "gnuradio-runtime"))
+  ]
+  ++ lib.mapAttrsToList (
     feat: info:
     (
       if feat == "basic" then
         # Abuse this unavoidable "iteration" to set this flag which we want as
         # well - it means: Don't turn on features just because their deps are
         # satisfied, let only our cmakeFlags decide.
-        "-DENABLE_DEFAULT=OFF"
-      else if hasFeature feat then
-        "-DENABLE_${info.cmakeEnableFlag}=ON"
+        (lib.cmakeBool "ENABLE_DEFAULT" false)
       else
-        "-DENABLE_${info.cmakeEnableFlag}=OFF"
+        (lib.cmakeBool "ENABLE_${info.cmakeEnableFlag}" (hasFeature feat))
     )
   ) featuresInfo;
   disallowedReferences = [
-    # TODO: Should this be conditional?
     stdenv.cc
     stdenv.cc.cc
   ]