diff --git a/pkgs/development/python-modules/nixpkgs/default.nix b/pkgs/development/python-modules/nixpkgs/default.nix
deleted file mode 100644
index 989eb91287d8..000000000000
--- a/pkgs/development/python-modules/nixpkgs/default.nix
+++ /dev/null
@@ -1,34 +0,0 @@
-{
-  lib,
-  buildPythonPackage,
-  fetchPypi,
-  pbr,
-  pythonix,
-  pythonAtLeast,
-}:
-
-buildPythonPackage rec {
-  pname = "nixpkgs";
-  version = "0.2.4";
-  format = "setuptools";
-  disabled = !pythonAtLeast "3.5";
-
-  src = fetchPypi {
-    inherit pname version;
-    sha256 = "0dlvq4bpamhlva86042wlc0xxfsxlpdgm2adfb1c6y3vjgbm0nvd";
-  };
-
-  buildInputs = [ pbr ];
-  propagatedBuildInputs = [ pythonix ];
-
-  # does not have any tests
-  doCheck = false;
-  pythonImportsCheck = [ "nixpkgs" ];
-
-  meta = with lib; {
-    description = "Allows to `from nixpkgs import` stuff in interactive Python sessions";
-    homepage = "https://github.com/t184256/nixpkgs-python-importer";
-    license = licenses.mit;
-    maintainers = with maintainers; [ t184256 ];
-  };
-}
diff --git a/pkgs/development/python-modules/pythonix/default.nix b/pkgs/development/python-modules/pythonix/default.nix
deleted file mode 100644
index 18eb56419219..000000000000
--- a/pkgs/development/python-modules/pythonix/default.nix
+++ /dev/null
@@ -1,54 +0,0 @@
-{
-  lib,
-  buildPythonPackage,
-  fetchFromGitHub,
-  ninja,
-  boost,
-  meson,
-  pkg-config,
-  nix,
-  isPy3k,
-  python,
-}:
-
-buildPythonPackage rec {
-  pname = "pythonix";
-  version = "0.1.7";
-  format = "other";
-
-  src = fetchFromGitHub {
-    owner = "Mic92";
-    repo = "pythonix";
-    rev = "v${version}";
-    sha256 = "1wxqv3i4bva2qq9mx670bcx0g0irjn68fvk28dwvhay9ndwcspqf";
-  };
-
-  disabled = !isPy3k;
-
-  nativeBuildInputs = [
-    meson
-    ninja
-    pkg-config
-  ];
-
-  buildInputs = [
-    nix
-    boost
-  ];
-
-  postInstall = ''
-    # This is typically set by pipInstallHook/eggInstallHook,
-    # so we have to do so manually when using meson
-    export PYTHONPATH=$out/${python.sitePackages}:$PYTHONPATH
-  '';
-
-  pythonImportsCheck = [ "nix" ];
-
-  meta = with lib; {
-    description = ''
-      Eval nix code from python.
-    '';
-    maintainers = [ ];
-    license = licenses.mit;
-  };
-}
diff --git a/pkgs/top-level/python-aliases.nix b/pkgs/top-level/python-aliases.nix
index ffa7b0460ef2..f0c7bbb6b415 100644
--- a/pkgs/top-level/python-aliases.nix
+++ b/pkgs/top-level/python-aliases.nix
@@ -455,6 +455,7 @@ mapAliases ({
   nghttp2 = throw "in 1.52.0 removed deprecated python bindings."; # added 2023-06-08
   niko-home-control = throw "niko-home-control was removed because Home Assistant switched to nhc"; # added 2025-01-09
   ninja-python = ninja; # add 2022-08-03
+  nixpkgs = throw "nixpkgs has been removed as its dependency pythonix was removed"; # added 2025-07-24
   nose = throw "nose has been removed since it has been deprecated and unmaintained for almost a decade and does not work on Python 3.12; please switch to pytest or another test runner/framework"; # added 2024-07-28
   nose3 = throw "nose3 has been removed since it is unmaintained and does not work with Python 3.12"; # added 2024-07-28
   nosejs = throw "nosejs has been removed since it has not been maintained for 15 years and there are no dependent packages"; # added 2024-05-21
@@ -588,6 +589,7 @@ mapAliases ({
   python-myq = throw "python-myq has been removed, as the service provider has decided to block its API requests"; # added 2023-12-07
   python-picnic-api = throw "python-picnic-api was removed because Home Assistant switched to python-picnic-api2"; # added 2025-03-05
   python-unshare = throw "python-unshare was removed as unmaintained since 2016"; # added 2025-05-25
+  pythonix = throw "pythonix was removed as it was unmaintained since 2022"; # added 2025-07-24
   pytrends = throw "pytrends has been removed, as it no longer works and is abandoned upstream"; # added 2025-02-02
   pyqldb = throw "pyqldb has been removed, because the underlying service is reaching end of support"; # added 2025-07-30
   pyqt4 = throw "pyqt4 has been removed, because it depended on the long EOL qt4"; # added 2022-06-09
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 19828a5367b9..b93f78a9ac72 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -10411,8 +10411,6 @@ self: super: with self; {
 
   nix-prefetch-github = callPackage ../development/python-modules/nix-prefetch-github { };
 
-  nixpkgs = callPackage ../development/python-modules/nixpkgs { };
-
   nixpkgs-pytools = callPackage ../development/python-modules/nixpkgs-pytools { };
 
   nixpkgs-updaters-library = callPackage ../development/python-modules/nixpkgs-updaters-library { };
@@ -14959,11 +14957,6 @@ self: super: with self; {
 
   pythonfinder = callPackage ../development/python-modules/pythonfinder { };
 
-  pythonix = callPackage ../development/python-modules/pythonix {
-    nix = pkgs.nixVersions.nix_2_3;
-    meson = pkgs.meson.override { python3 = self.python; };
-  };
-
   pythonkuma = callPackage ../development/python-modules/pythonkuma { };
 
   pythonnet = callPackage ../development/python-modules/pythonnet { };