diff --git a/pkgs/development/libraries/ffmpeg/generic.nix b/pkgs/development/libraries/ffmpeg/generic.nix
index eb8c60e3eb27..94e86bfa09ad 100644
--- a/pkgs/development/libraries/ffmpeg/generic.nix
+++ b/pkgs/development/libraries/ffmpeg/generic.nix
@@ -707,8 +707,8 @@ stdenv.mkDerivation (finalAttrs: {
     "--enable-cross-compile"
     "--host-cc=${buildPackages.stdenv.cc}/bin/cc"
   ] ++ optionals stdenv.cc.isClang [
-    "--cc=clang"
-    "--cxx=clang++"
+    "--cc=${stdenv.cc.targetPrefix}clang"
+    "--cxx=${stdenv.cc.targetPrefix}clang++"
   ] ++ optionals withMetal [
     "--metalcc=${xcode}/Contents/Developer/Toolchains/XcodeDefault.xctoolchain/usr/bin/metal"
     "--metallib=${xcode}/Contents/Developer/Toolchains/XcodeDefault.xctoolchain/usr/bin/metallib"