diff --git a/nixos/modules/virtualisation/virtualbox-guest.nix b/nixos/modules/virtualisation/virtualbox-guest.nix
index 68731ddc1783..66b0aeb83c7a 100644
--- a/nixos/modules/virtualisation/virtualbox-guest.nix
+++ b/nixos/modules/virtualisation/virtualbox-guest.nix
@@ -104,7 +104,7 @@ in
       {
         assertions = [
           {
-            assertion = pkgs.stdenv.hostPlatform.isx86;
+            assertion = pkgs.stdenv.hostPlatform.isx86 || pkgs.stdenv.hostPlatform.isAarch64;
             message = "Virtualbox not currently supported on ${pkgs.stdenv.hostPlatform.system}";
           }
         ];
diff --git a/pkgs/applications/virtualization/virtualbox/guest-additions/builder.nix b/pkgs/applications/virtualization/virtualbox/guest-additions/builder.nix
index a955a9551ed4..732b3923249a 100644
--- a/pkgs/applications/virtualization/virtualbox/guest-additions/builder.nix
+++ b/pkgs/applications/virtualization/virtualbox/guest-additions/builder.nix
@@ -23,6 +23,7 @@
   virtualboxVersion,
   virtualboxSubVersion,
   virtualboxSha256,
+  platform,
 }:
 
 let
@@ -77,13 +78,15 @@ stdenv.mkDerivation (finalAttrs: {
     rm -r src/libs/zlib*/
   '';
 
+  # Apply fix for: https://www.virtualbox.org/ticket/22397
+  patches = lib.optional stdenv.hostPlatform.isAarch64 ./guest-additions-aarch64-fix.patch;
+
   postPatch = ''
     set -x
     sed -e 's@MKISOFS --version@MKISOFS -version@' \
         -e 's@CXX_FLAGS="\(.*\)"@CXX_FLAGS="-std=c++17 \1"@' \
         -i configure
-    ls kBuild/bin/linux.x86/k* tools/linux.x86/bin/* | xargs -n 1 patchelf --set-interpreter ${stdenv.cc.libc}/lib/ld-linux.so.2
-    ls kBuild/bin/linux.amd64/k* tools/linux.amd64/bin/* | xargs -n 1 patchelf --set-interpreter ${stdenv.cc.libc}/lib/ld-linux-x86-64.so.2
+    ls kBuild/bin/linux.${platform}/k* tools/linux.${platform}/bin/* | xargs -n 1 patchelf --set-interpreter ${stdenv.cc.bintools.dynamicLinker}
 
     substituteInPlace ./include/VBox/dbus-calls.h --replace-fail libdbus-1.so.3 ${dbus.lib}/lib/libdbus-1.so.3
 
@@ -166,11 +169,7 @@ stdenv.mkDerivation (finalAttrs: {
     runHook preInstall
 
     mkdir -p $out
-    cp -rv ./out/linux.${
-      if stdenv.hostPlatform.is32bit then "x86" else "amd64"
-    }/${buildType}/bin/additions/VBoxGuestAdditions-${
-      if stdenv.hostPlatform.is32bit then "x86" else "amd64"
-    }.tar.bz2 $out/
+    cp -rv ./out/linux.${platform}/${buildType}/bin/additions/VBoxGuestAdditions-${platform}.tar.bz2 $out/
 
     runHook postInstall
   '';
diff --git a/pkgs/applications/virtualization/virtualbox/guest-additions/default.nix b/pkgs/applications/virtualization/virtualbox/guest-additions/default.nix
index 9a7d0e2e6227..7c360b9a18cf 100644
--- a/pkgs/applications/virtualization/virtualbox/guest-additions/default.nix
+++ b/pkgs/applications/virtualization/virtualbox/guest-additions/default.nix
@@ -16,8 +16,21 @@ let
   virtualboxSubVersion = "";
   virtualboxSha256 = "6f9618f39168898134975f51df7c2d6d5129c0aa82b6ae11cf47f920c70df276";
 
+  platform =
+    if stdenv.hostPlatform.isAarch64 then
+      "arm64"
+    else if stdenv.hostPlatform.is32bit then
+      "x86"
+    else
+      "amd64";
+
   virtualBoxNixGuestAdditionsBuilder = callPackage ./builder.nix {
-    inherit virtualboxVersion virtualboxSubVersion virtualboxSha256;
+    inherit
+      virtualboxVersion
+      virtualboxSubVersion
+      virtualboxSha256
+      platform
+      ;
   };
 
   # Specifies how to patch binaries to make sure that libraries loaded using
@@ -54,9 +67,7 @@ stdenv.mkDerivation {
   pname = "VirtualBox-GuestAdditions";
   version = "${virtualboxVersion}${virtualboxSubVersion}-${kernel.version}";
 
-  src = "${virtualBoxNixGuestAdditionsBuilder}/VBoxGuestAdditions-${
-    if stdenv.hostPlatform.is32bit then "x86" else "amd64"
-  }.tar.bz2";
+  src = "${virtualBoxNixGuestAdditionsBuilder}/VBoxGuestAdditions-${platform}.tar.bz2";
   sourceRoot = ".";
 
   KERN_DIR = "${kernel.dev}/lib/modules/${kernel.modDirVersion}/build";
@@ -159,6 +170,7 @@ stdenv.mkDerivation {
     platforms = [
       "i686-linux"
       "x86_64-linux"
+      "aarch64-linux"
     ];
     broken = stdenv.hostPlatform.is32bit && (kernel.kernelAtLeast "5.10");
   };
diff --git a/pkgs/applications/virtualization/virtualbox/guest-additions/guest-additions-aarch64-fix.patch b/pkgs/applications/virtualization/virtualbox/guest-additions/guest-additions-aarch64-fix.patch
new file mode 100644
index 000000000000..e787da94dcc1
--- /dev/null
+++ b/pkgs/applications/virtualization/virtualbox/guest-additions/guest-additions-aarch64-fix.patch
@@ -0,0 +1,15 @@
+diff --git a/configure b/configure
+index e845993..a5b526e 100644q
+--- a/configure
++++ b/configure
+@@ -422,6 +422,10 @@ check_environment()
+         BUILD_MACHINE='sparc32'
+         BUILD_CPU='blend'
+         ;;
++    aarch64)
++        BUILD_MACHINE='arm64'
++        BUILD_CPU='blend'
++        ;;
+     *)
+       log_failure "Cannot determine system"
+       exit 1
\ No newline at end of file