diff --git a/pkgs/development/python-modules/otr/default.nix b/pkgs/development/python-modules/otr/default.nix
new file mode 100644
index 000000000000..38e1927c129b
--- /dev/null
+++ b/pkgs/development/python-modules/otr/default.nix
@@ -0,0 +1,49 @@
+{
+  lib,
+  buildPythonPackage,
+  fetchFromGitHub,
+  setuptools,
+  cryptography,
+  gmpy2,
+  python3-application,
+}:
+
+buildPythonPackage rec {
+  pname = "otr";
+  version = "2.1.0";
+  pyproject = true;
+
+  src = fetchFromGitHub {
+    owner = "AGProjects";
+    repo = "python3-otr";
+    tag = version;
+    hash = "sha256-jCyPEdWDEW1x0Id//yM67SvKvYpdyIfPmcCWiRgwvb0=";
+  };
+
+  build-system = [ setuptools ];
+
+  dependencies = [
+    cryptography
+    gmpy2
+    python3-application
+  ];
+
+  checkPhase = ''
+    runHook preCheck
+
+    python3 test.py
+
+    runHook postCheck
+  '';
+
+  pythonImportsCheck = [ "otr" ];
+
+  meta = {
+    description = "Off-The-Record Messaging protocol implementation for Python";
+    homepage = "https://github.com/AGProjects/python3-otr";
+    license = lib.licenses.lgpl21Plus;
+    teams = [
+      lib.teams.ngi
+    ];
+  };
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index f6d38532657a..8d1b10cd1642 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -11094,6 +11094,8 @@ self: super: with self; {
 
   otpauth = callPackage ../development/python-modules/otpauth { };
 
+  otr = callPackage ../development/python-modules/otr { };
+
   ots-python = callPackage ../development/python-modules/ots-python { };
 
   ourgroceries = callPackage ../development/python-modules/ourgroceries { };